A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems()

The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine–arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against...

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Detalles Bibliográficos
Autores principales: Massaoka, Mariana H., Matsuo, Alisson L., Figueiredo, Carlos R., Girola, Natalia, Faria, Camyla F., Azevedo, Ricardo A., Travassos, Luiz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907745/
https://www.ncbi.nlm.nih.gov/pubmed/24490140
http://dx.doi.org/10.1016/j.fob.2014.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907745/
https://www.ncbi.nlm.nih.gov/pubmed/24490140
http://dx.doi.org/10.1016/j.fob.2014.01.007

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