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Biochemical reconstitution of topological DNA binding by the cohesin ring
Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a prerequisite for faithful chromosome segregation in mitosis. Cohesin plays vital roles also in DNA repair and transcriptional regulation. The ring-shaped cohesin complex is thought to encircle sister DNA strands, b...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907785/ https://www.ncbi.nlm.nih.gov/pubmed/24291789 http://dx.doi.org/10.1038/nature12867 |