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Biochemical reconstitution of topological DNA binding by the cohesin ring

Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a prerequisite for faithful chromosome segregation in mitosis. Cohesin plays vital roles also in DNA repair and transcriptional regulation. The ring-shaped cohesin complex is thought to encircle sister DNA strands, b...

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Detalles Bibliográficos
Autores principales: Murayama, Yasuto, Uhlmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907785/
https://www.ncbi.nlm.nih.gov/pubmed/24291789
http://dx.doi.org/10.1038/nature12867