Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

We performed in vivo and in vitro studies to determine the induction of human cytochrome P450 (CYP) using chimeric mice with humanized liver (PXB-mice(®)) and human hepatocytes isolated from the PXB-mice (PXB-cells), which were derived from the same donor. For the in vivo study, PXB-mice were inject...

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Detalles Bibliográficos
Autores principales: Kakuni, Masakazu, Yamasaki, Chihiro, Tachibana, Asato, Yoshizane, Yasumi, Ishida, Yuji, Tateno, Chise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907798/
https://www.ncbi.nlm.nih.gov/pubmed/24362577
http://dx.doi.org/10.3390/ijms15010058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907798/
https://www.ncbi.nlm.nih.gov/pubmed/24362577
http://dx.doi.org/10.3390/ijms15010058

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