Molecular Dynamics Simulation of the Crystallizable Fragment of IgG1—Insights for the Design of Fcabs

An interesting format in the development of therapeutic monoclonal antibodies uses the crystallizable fragment of IgG1 as starting scaffold. Engineering of its structural loops allows generation of an antigen binding site. However, this might impair the molecule’s conformational stability, which can...

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Detalles Bibliográficos
Autores principales: Lai, Balder, Hasenhindl, Christoph, Obinger, Christian, Oostenbrink, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907818/
https://www.ncbi.nlm.nih.gov/pubmed/24451126
http://dx.doi.org/10.3390/ijms15010438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907818/
https://www.ncbi.nlm.nih.gov/pubmed/24451126
http://dx.doi.org/10.3390/ijms15010438

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