In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants

The aggregation of alpha-synuclein (α-SYN) into fibrils is characteristic for several neurodegenerative diseases, including Parkinson’s disease (PD). Ninety percent of α-SYN deposited in Lewy Bodies, a pathological hallmark of PD, is phosphorylated on serine129. α-SYN can also be phosphorylated on t...

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Detalles Bibliográficos
Autores principales: Schreurs, Sarah, Gerard, Melanie, Derua, Rita, Waelkens, Etienne, Taymans, Jean-Marc, Baekelandt, Veerle, Engelborghs, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907855/
https://www.ncbi.nlm.nih.gov/pubmed/24434619
http://dx.doi.org/10.3390/ijms15011040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907855/
https://www.ncbi.nlm.nih.gov/pubmed/24434619
http://dx.doi.org/10.3390/ijms15011040

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