Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells

Hyperleptinemia is implicated in obesity-associated lumbar disc degeneration. Nevertheless, the effect of leptin on the intracellular signaling of nucleus pulposus cells is not clear. The current study sought to delineate the possible involvement of the RhoA/ROCK pathway in leptin-mediated cytoskele...

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Detalles Bibliográficos
Autores principales: Li, Zheng, Liang, Jinqian, Wu, William Ka Kei, Yu, Xin, Yu, Jun, Weng, Xisheng, Shen, Jianxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907862/
https://www.ncbi.nlm.nih.gov/pubmed/24441571
http://dx.doi.org/10.3390/ijms15011176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907862/
https://www.ncbi.nlm.nih.gov/pubmed/24441571
http://dx.doi.org/10.3390/ijms15011176

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