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Phenoxybenzamine Is Neuroprotective in a Rat Model of Severe Traumatic Brain Injury

Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening neuroprotective candidates, we found that phenoxybe...

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Detalles Bibliográficos
Autores principales: Rau, Thomas F., Kothiwal, Aakriti, Rova, Annela, Rhoderick, Joseph F., Poulsen, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907876/
https://www.ncbi.nlm.nih.gov/pubmed/24447929
http://dx.doi.org/10.3390/ijms15011402