Regulated expression of CXCR4 constitutive active mutants revealed the up-modulated chemotaxis and up-regulation of genes crucial for CXCR4 mediated homing and engraftment of hematopoietic stem/progenitor cells

SDF-1/CXCR4 axis plays a principle role in the homing and engraftment of hematopoietic stem/progenitor cells (HSPCs), a process that defines cells ability to reach and seed recipient bone marrow niche following their intravenous infusion. However, the proper functioning of CXCR4 downstream signaling...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, M, Afrin, F, Tripathi, RP, Gangenahalli, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Stem Cells and Regenerative Medicine 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908308/
https://www.ncbi.nlm.nih.gov/pubmed/24693205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908308/
https://www.ncbi.nlm.nih.gov/pubmed/24693205

Ejemplares similares