Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

Activation of mammalian target of rapamycin complex 1 (mTORC1) by amino acids is mediated in part by the Rag GTPases, which bind the raptor subunit of mTORC1 in an amino acid-stimulated manner and promote mTORC1 interaction with Rheb-GTP, the immediate activator. Here we examine whether the ability...

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Detalles Bibliográficos
Autores principales: Oshiro, Noriko, Rapley, Joseph, Avruch, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908400/
https://www.ncbi.nlm.nih.gov/pubmed/24337580
http://dx.doi.org/10.1074/jbc.M113.528505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908400/
https://www.ncbi.nlm.nih.gov/pubmed/24337580
http://dx.doi.org/10.1074/jbc.M113.528505

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