Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry

PURPOSE: Constitutional MLH1 epimutations manifest as promoter methylation and silencing of the affected allele in normal tissues, predisposing to Lynch syndrome–associated cancers. This study investigated their frequency and inheritance. METHODS: A total of 416 individuals with a colorectal cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: Ward, Robyn L., Dobbins, Timothy, Lindor, Noralane M., Rapkins, Robert W., Hitchins, Megan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908650/
https://www.ncbi.nlm.nih.gov/pubmed/22878509
http://dx.doi.org/10.1038/gim.2012.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908650/
https://www.ncbi.nlm.nih.gov/pubmed/22878509
http://dx.doi.org/10.1038/gim.2012.91

Ejemplares similares