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Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry

PURPOSE: Constitutional MLH1 epimutations manifest as promoter methylation and silencing of the affected allele in normal tissues, predisposing to Lynch syndrome–associated cancers. This study investigated their frequency and inheritance. METHODS: A total of 416 individuals with a colorectal cancer...

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Detalles Bibliográficos
Autores principales:	Ward, Robyn L., Dobbins, Timothy, Lindor, Noralane M., Rapkins, Robert W., Hitchins, Megan P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908650/ https://www.ncbi.nlm.nih.gov/pubmed/22878509 http://dx.doi.org/10.1038/gim.2012.91

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