Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes

BACKGROUND: Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purpose of this study was to assess the effect of genetic factors on EFV pharmacokinetics, treatment outcomes and genotype ba...

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Detalles Bibliográficos
Autores principales: Mukonzo, Jackson K., Owen, Joel S., Ogwal-Okeng, Jasper, Kuteesa, Ronald B., Nanzigu, Sarah, Sewankambo, Nelson, Thabane, Lehana, Gustafsson, Lars L., Ross, Colin, Aklillu, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909010/
https://www.ncbi.nlm.nih.gov/pubmed/24497997
http://dx.doi.org/10.1371/journal.pone.0086919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909010/
https://www.ncbi.nlm.nih.gov/pubmed/24497997
http://dx.doi.org/10.1371/journal.pone.0086919

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