Fluphenazine Reduces Proteotoxicity in C. elegans and Mammalian Models of Alpha-1-Antitrypsin Deficiency

The classical form of α1-antitrypsin deficiency (ATD) is associated with hepatic fibrosis and hepatocellular carcinoma. It is caused by the proteotoxic effect of a mutant secretory protein that aberrantly accumulates in the endoplasmic reticulum of liver cells. Recently we developed a model of this...

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Detalles Bibliográficos
Autores principales: Li, Jie, Pak, Stephen C., O’Reilly, Linda P., Benson, Joshua A., Wang, Yan, Hidvegi, Tunda, Hale, Pamela, Dippold, Christine, Ewing, Michael, Silverman, Gary A., Perlmutter, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909079/
https://www.ncbi.nlm.nih.gov/pubmed/24498058
http://dx.doi.org/10.1371/journal.pone.0087260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909079/
https://www.ncbi.nlm.nih.gov/pubmed/24498058
http://dx.doi.org/10.1371/journal.pone.0087260

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