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β-Hairpin-Mediated Formation of Structurally Distinct Multimers of Neurotoxic Prion Peptides
Protein misfolding disorders are associated with conformational changes in specific proteins, leading to the formation of potentially neurotoxic amyloid fibrils. During pathogenesis of prion disease, the prion protein misfolds into β-sheet rich, protease-resistant isoforms. A key, hydrophobic domain...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909104/ https://www.ncbi.nlm.nih.gov/pubmed/24498083 http://dx.doi.org/10.1371/journal.pone.0087354 |