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ERK MAP Kinase Activation in Spinal Cord Regulates Phosphorylation of Cdk5 at Serine 159 and Contributes to Peripheral Inflammation Induced Pain/Hypersensitivity
Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 activation. However, it is still unclear whether...
Autores principales: | Zhang, Xiaoqin, Zhang, Honghai, Shao, Haijun, Xue, Qingsheng, Yu, Buwei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909239/ https://www.ncbi.nlm.nih.gov/pubmed/24498195 http://dx.doi.org/10.1371/journal.pone.0087788 |
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