Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7 regulates progression through S phase. We have used a Cdc7 inhibitor, PHA-767491, to dissect t...

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Detalles Bibliográficos
Autores principales: Poh, Wei Theng, Chadha, Gaganmeet Singh, Gillespie, Peter J., Kaldis, Philipp, Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909274/
https://www.ncbi.nlm.nih.gov/pubmed/24403013
http://dx.doi.org/10.1098/rsob.130138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909274/
https://www.ncbi.nlm.nih.gov/pubmed/24403013
http://dx.doi.org/10.1098/rsob.130138

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