A thermodynamic assay to test pharmacological chaperones for Fabry disease()

BACKGROUND: The majority of the disease-causing mutations affect protein stability, but not functional sites and are amenable, in principle, to be treated with pharmacological chaperones. These drugs enhance the thermodynamic stability of their targets. Fabry disease, a disorder caused by mutations...

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Detalles Bibliográficos
Autores principales: Andreotti, Giuseppina, Citro, Valentina, Correra, Antonella, Cubellis, Maria Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909460/
https://www.ncbi.nlm.nih.gov/pubmed/24361605
http://dx.doi.org/10.1016/j.bbagen.2013.12.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909460/
https://www.ncbi.nlm.nih.gov/pubmed/24361605
http://dx.doi.org/10.1016/j.bbagen.2013.12.018

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