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Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1()
Glyoxalase 1 (GlxI) is the key enzyme that converts the highly reactive α-oxo-aldehydes into the corresponding α-hydroxy acids using l-glutathione as a cofactor. In our preliminary data, GlxI was identified as a substrate of transglutaminase 2 (TG2), a ubiquitous enzyme with multiple functions. Acco...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909781/ https://www.ncbi.nlm.nih.gov/pubmed/24494193 http://dx.doi.org/10.1016/j.redox.2013.12.024 |