Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways

Lubricin is a secreted proteoglycan encoded by the Prg4 locus that is abundantly expressed by superficial zone articular chondrocytes and has been noted to both be sensitive to mechanical loading and protect against the development of osteoarthritis. In this study, we document that running induces m...

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Detalles Bibliográficos
Autores principales: Ogawa, Hiroyasu, Kozhemyakina, Elena, Hung, Han-Hwa, Grodzinsky, Alan J., Lassar, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909787/
https://www.ncbi.nlm.nih.gov/pubmed/24449269
http://dx.doi.org/10.1101/gad.231969.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909787/
https://www.ncbi.nlm.nih.gov/pubmed/24449269
http://dx.doi.org/10.1101/gad.231969.113

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