A Multiscale Model of Interleukin-6–Mediated Immune Regulation in Crohn's Disease and Its Application in Drug Discovery and Development

In this study, we have developed a multiscale systems model of interleukin (IL)-6–mediated immune regulation in Crohn's disease, by integrating intracellular signaling with organ-level dynamics of pharmacological markers underlying the disease. This model was linked to a general pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Dwivedi, G, Fitz, L, Hegen, M, Martin, S W, Harrold, J, Heatherington, A, Li, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910013/
https://www.ncbi.nlm.nih.gov/pubmed/24402116
http://dx.doi.org/10.1038/psp.2013.64

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910013/
https://www.ncbi.nlm.nih.gov/pubmed/24402116
http://dx.doi.org/10.1038/psp.2013.64

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