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Identifying Druggable Targets by Protein Microenvironments Matching: Application to Transcription Factors
Druggability of a protein is its potential to be modulated by drug-like molecules. It is important in the target selection phase. We hypothesize that: (i) known drug-binding sites contain advantageous physicochemical properties for drug binding, or “druggable microenvironments” and (ii) given a targ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910014/ https://www.ncbi.nlm.nih.gov/pubmed/24452614 http://dx.doi.org/10.1038/psp.2013.66 |