A General Network Pharmacodynamic Model–Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway

A unified approach to optimize multidrug chemotherapy using a pharmacokinetic (PK)/enhanced pharmacodynamic model was developed using the vascular endothelial growth factor receptor (VEGFR) signaling system. The base VEGFR network model, characterized by ligand–receptor interactions, enzyme recruitm...

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Detalles Bibliográficos
Autores principales: Zhang, X-Y, Birtwistle, M R, Gallo, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910016/
https://www.ncbi.nlm.nih.gov/pubmed/24429593
http://dx.doi.org/10.1038/psp.2013.65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910016/
https://www.ncbi.nlm.nih.gov/pubmed/24429593
http://dx.doi.org/10.1038/psp.2013.65

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