Stem cell expansion during carcinogenesis in stem cell depleted conditional telomeric repeat factor 2 null mutant mice

To examine the role of TRF2 in epithelial tumorigenesis, we characterized conditional loss of TRF2 expression in the basal layer of mouse epidermis. These mice exhibit some characteristics of dyskeratosis congenita, a human stem cell depletion syndrome caused by telomere dysfunction. The epidermis i...

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Detalles Bibliográficos
Autores principales: Bojovic, Bojana, Ho, Hoang-Yen, Wu, Jianchun, Crowe, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910501/
https://www.ncbi.nlm.nih.gov/pubmed/23178498
http://dx.doi.org/10.1038/onc.2012.555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910501/
https://www.ncbi.nlm.nih.gov/pubmed/23178498
http://dx.doi.org/10.1038/onc.2012.555

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