Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

BACKGROUND: Despite aggressive treatment with radiation therapy and concurrent adjuvant temozolomide (TMZ), glioblastoma multiform (GBM) still has a dismal prognosis. We aimed to identify strategies to improve the therapeutic outcome of combined radiotherapy and TMZ in GBM by targeting pro-survival...

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Detalles Bibliográficos
Autores principales: Choi, Eun Jung, Cho, Bong Jun, Lee, David J, Hwang, Yeo Hyeon, Chun, Sun Ha, Kim, Hans H, Kim, In Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910677/
https://www.ncbi.nlm.nih.gov/pubmed/24418474
http://dx.doi.org/10.1186/1471-2407-14-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910677/
https://www.ncbi.nlm.nih.gov/pubmed/24418474
http://dx.doi.org/10.1186/1471-2407-14-17

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