Powerful Sequence Similarity Search Methods and In-Depth Manual Analyses Can Identify Remote Homologs in Many Apparently “Orphan” Viral Proteins

The genome sequences of new viruses often contain many “orphan” or “taxon-specific” proteins apparently lacking homologs. However, because viral proteins evolve very fast, commonly used sequence similarity detection methods such as BLAST may overlook homologs. We analyzed a data set of proteins from...

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Detalles Bibliográficos
Autores principales: Kuchibhatla, Durga B., Sherman, Westley A., Chung, Betty Y. W., Cook, Shelley, Schneider, Georg, Eisenhaber, Birgit, Karlin, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911697/
https://www.ncbi.nlm.nih.gov/pubmed/24155369
http://dx.doi.org/10.1128/JVI.02595-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911697/
https://www.ncbi.nlm.nih.gov/pubmed/24155369
http://dx.doi.org/10.1128/JVI.02595-13

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