Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections

At mucosal sites, papillomavirus genomes can persist in the epithelial basal layer following immune-mediated regression. Subsequent T-cell depletion stimulates a 3- to 5-log increase in the viral copy number, to levels associated with productive infection. Reappearance of microlesions was rare withi...

Descripción completa

Detalles Bibliográficos
Autores principales: Maglennon, G. A., McIntosh, P. B., Doorbar, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911712/
https://www.ncbi.nlm.nih.gov/pubmed/24173230
http://dx.doi.org/10.1128/JVI.02589-13
_version_ 1782302001063788544
author Maglennon, G. A.
McIntosh, P. B.
Doorbar, J.
author_facet Maglennon, G. A.
McIntosh, P. B.
Doorbar, J.
author_sort Maglennon, G. A.
collection PubMed
description At mucosal sites, papillomavirus genomes can persist in the epithelial basal layer following immune-mediated regression. Subsequent T-cell depletion stimulates a 3- to 5-log increase in the viral copy number, to levels associated with productive infection. Reappearance of microlesions was rare within the short time frame of our experiments but was observed in one instance. Our studies provide direct evidence that immunosuppression can trigger the reactivation of latent papillomavirus genomes, as previously proposed in humans.
format Online
Article
Text
id pubmed-3911712
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-39117122014-02-05 Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections Maglennon, G. A. McIntosh, P. B. Doorbar, J. J Virol Pathogenesis and Immunity At mucosal sites, papillomavirus genomes can persist in the epithelial basal layer following immune-mediated regression. Subsequent T-cell depletion stimulates a 3- to 5-log increase in the viral copy number, to levels associated with productive infection. Reappearance of microlesions was rare within the short time frame of our experiments but was observed in one instance. Our studies provide direct evidence that immunosuppression can trigger the reactivation of latent papillomavirus genomes, as previously proposed in humans. American Society for Microbiology 2014-01 /pmc/articles/PMC3911712/ /pubmed/24173230 http://dx.doi.org/10.1128/JVI.02589-13 Text en Copyright © 2014 Maglennon et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Pathogenesis and Immunity
Maglennon, G. A.
McIntosh, P. B.
Doorbar, J.
Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
title Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
title_full Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
title_fullStr Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
title_full_unstemmed Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
title_short Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
title_sort immunosuppression facilitates the reactivation of latent papillomavirus infections
topic Pathogenesis and Immunity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911712/
https://www.ncbi.nlm.nih.gov/pubmed/24173230
http://dx.doi.org/10.1128/JVI.02589-13
work_keys_str_mv AT maglennonga immunosuppressionfacilitatesthereactivationoflatentpapillomavirusinfections
AT mcintoshpb immunosuppressionfacilitatesthereactivationoflatentpapillomavirusinfections
AT doorbarj immunosuppressionfacilitatesthereactivationoflatentpapillomavirusinfections

Ejemplares similares