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A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a st...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911877/ https://www.ncbi.nlm.nih.gov/pubmed/24316715 http://dx.doi.org/10.1038/nchembio.1432 |