A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation

N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a st...

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Detalles Bibliográficos
Autores principales: Liu, Jianzhao, Yue, Yanan, Han, Dali, Wang, Xiao, Fu, Ye, Zhang, Liang, Jia, Guifang, Yu, Miao, Lu, Zhike, Deng, Xin, Dai, Qing, Chen, Weizhong, He, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911877/
https://www.ncbi.nlm.nih.gov/pubmed/24316715
http://dx.doi.org/10.1038/nchembio.1432
Descripción
Sumario:N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.

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