A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation

N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a st...

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Autores principales: Liu, Jianzhao, Yue, Yanan, Han, Dali, Wang, Xiao, Fu, Ye, Zhang, Liang, Jia, Guifang, Yu, Miao, Lu, Zhike, Deng, Xin, Dai, Qing, Chen, Weizhong, He, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911877/
https://www.ncbi.nlm.nih.gov/pubmed/24316715
http://dx.doi.org/10.1038/nchembio.1432
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author Liu, Jianzhao
Yue, Yanan
Han, Dali
Wang, Xiao
Fu, Ye
Zhang, Liang
Jia, Guifang
Yu, Miao
Lu, Zhike
Deng, Xin
Dai, Qing
Chen, Weizhong
He, Chuan
author_facet Liu, Jianzhao
Yue, Yanan
Han, Dali
Wang, Xiao
Fu, Ye
Zhang, Liang
Jia, Guifang
Yu, Miao
Lu, Zhike
Deng, Xin
Dai, Qing
Chen, Weizhong
He, Chuan
author_sort Liu, Jianzhao
collection PubMed
description N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.
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spelling pubmed-39118772014-08-01 A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation Liu, Jianzhao Yue, Yanan Han, Dali Wang, Xiao Fu, Ye Zhang, Liang Jia, Guifang Yu, Miao Lu, Zhike Deng, Xin Dai, Qing Chen, Weizhong He, Chuan Nat Chem Biol Article N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation. 2013-12-06 2014-02 /pmc/articles/PMC3911877/ /pubmed/24316715 http://dx.doi.org/10.1038/nchembio.1432 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Liu, Jianzhao
Yue, Yanan
Han, Dali
Wang, Xiao
Fu, Ye
Zhang, Liang
Jia, Guifang
Yu, Miao
Lu, Zhike
Deng, Xin
Dai, Qing
Chen, Weizhong
He, Chuan
A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
title A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
title_full A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
title_fullStr A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
title_full_unstemmed A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
title_short A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
title_sort mettl3-mettl14 complex mediates mammalian nuclear rna n(6)-adenosine methylation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911877/
https://www.ncbi.nlm.nih.gov/pubmed/24316715
http://dx.doi.org/10.1038/nchembio.1432
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