Cargando…

A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation

N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jianzhao, Yue, Yanan, Han, Dali, Wang, Xiao, Fu, Ye, Zhang, Liang, Jia, Guifang, Yu, Miao, Lu, Zhike, Deng, Xin, Dai, Qing, Chen, Weizhong, He, Chuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911877/ https://www.ncbi.nlm.nih.gov/pubmed/24316715 http://dx.doi.org/10.1038/nchembio.1432

Ejemplares similares

Analysis of METTL3 and METTL14 in hepatocellular carcinoma
por: Liu, Xiangxiang, et al.
Publicado: (2020)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators
por: Selberg, Simona, et al.
Publicado: (2021)

RNA binding to human METTL3-METTL14 restricts N(6)-deoxyadenosine methylation of DNA in vitro
por: Qi, Shan, et al.
Publicado: (2022)

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

Targeting METTL14 and RNA methylation to treat osteosarcoma
por: Ren, Lili, et al.
Publicado: (2022)

WTAP–VIRMA counteracts dsDNA binding of the m(6)A writer METTL3–METTL14 complex and maintains N(6)-adenosine methylation activity
por: Yan, Xuhui, et al.
Publicado: (2023)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

Correction: Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

METTL14-mediated RNA methylation in digestive system tumors
por: Hu, Jiexuan, et al.
Publicado: (2023)

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

Insights into roles of METTL14 in tumors
por: Liu, Xin, et al.
Publicado: (2021)

Upregulation of METTL14 mediates the elevation of PERP mRNA N(6) adenosine methylation promoting the growth and metastasis of pancreatic cancer
por: Wang, Min, et al.
Publicado: (2020)

The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer
por: Ge, Yiling, et al.
Publicado: (2023)

PRMT1 methylates METTL14 to modulate its oncogenic function
por: Wang, Jingchao, et al.
Publicado: (2023)

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
por: Kobayashi, Masatoshi, et al.
Publicado: (2018)

Interactions, localization, and phosphorylation of the m(6)A generating METTL3–METTL14–WTAP complex
por: Schöller, Eva, et al.
Publicado: (2018)

A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing
por: Qi, Shan, et al.
Publicado: (2023)

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
por: Guan, Qian, et al.
Publicado: (2022)

METTL3/METTL14 Transactivation and m(6)A-Dependent TGF-β1 Translation in Activated Kupffer Cells
por: Feng, Yue, et al.
Publicado: (2021)

The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1‐positive acute lymphoblastic leukemia
por: Sun, Congcong, et al.
Publicado: (2019)

Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13
por: Parker, Haley V., et al.
Publicado: (2023)

Localization of METTL16 at the Nuclear Periphery and the Nucleolus Is Cell Cycle-Specific and METTL16 Interacts with Several Nucleolar Proteins
por: Stixová, Lenka, et al.
Publicado: (2021)

m(6)A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
por: Liu, Pingyu, et al.
Publicado: (2021)

Oxford on Its Mettle
Publicado: (1891)

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression
por: Yan, Chaojun, et al.
Publicado: (2023)

Knockdown of METTL14 inhibits the growth and invasion of cervical cancer
por: Geng, Feng, et al.
Publicado: (2019)

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
por: Yu, Dan, et al.
Publicado: (2021)

Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing’s sarcoma
por: Jiang, Jie, et al.
Publicado: (2022)

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro
por: Woodcock, Clayton B., et al.
Publicado: (2019)

Structural insights into molecular mechanism for N(6)-adenosine methylation by MT-A70 family methyltransferase METTL4
por: Luo, Qiang, et al.
Publicado: (2022)

The emerging importance of METTL5-mediated ribosomal RNA methylation
por: Turkalj, Elena M., et al.
Publicado: (2022)

7SK methylation by METTL3 promotes transcriptional activity
por: Perez-Pepe, Marcelo, et al.
Publicado: (2023)

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis
por: Lang, Fengchao, et al.
Publicado: (2019)

The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
por: Shi, Bin, et al.
Publicado: (2022)

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
por: Davydova, Erna, et al.
Publicado: (2021)

Lamin A safeguards the m(6)A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence
por: Zhang, Jie, et al.
Publicado: (2020)

Functional Characterization of Two RNA Methyltransferase Genes METTL3 and METTL14 Uncovers the Roles of m(6)A in Mediating Adaptation of Plutella xylostella to Host Plants
por: Wang, Bei-Bei, et al.
Publicado: (2022)

The m(6)A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia
por: Sang, Lina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_58l69jghdf1e6gdijvajdnphis