Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells

A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk factor for human autoimmunity. LYP is a known negative regulator of signaling through the T cell receptor (TCR), and murine Ptpn22 plays a role in thymic selection. However, the mechanism of action of...

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Detalles Bibliográficos
Autores principales: Wu, Dennis J., Zhou, Wenbo, Enouz, Sarah, Orrú, Valeria, Stanford, Stephanie M., Maine, Christian J., Rapini, Novella, Sawatzke, Kristy, Engel, Isaac, Fiorillo, Edoardo, Sherman, Linda A., Kronenberg, Mitch, Zehn, Dietmar, Peterson, Erik, Bottini, Nunzio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911918/
https://www.ncbi.nlm.nih.gov/pubmed/24498279
http://dx.doi.org/10.1371/journal.pone.0086677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911918/
https://www.ncbi.nlm.nih.gov/pubmed/24498279
http://dx.doi.org/10.1371/journal.pone.0086677

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