The Islet Estrogen Receptor-α Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes

The female steroid, 17β-estradiol (E2), is important for pancreatic β-cell function and acts via at least three estrogen receptors (ER), ERα, ERβ, and the G-protein coupled ER (GPER). Using a pancreas-specific ERα knockout mouse generated using the Cre-lox-P system and a Pdx1-Cre transgenic line (PE...

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Detalles Bibliográficos
Autores principales: Kilic, Gamze, Alvarez-Mercado, Ana I., Zarrouki, Bader, Opland, Darren, Liew, Chong Wee, Alonso, Laura C., Myers, Martin G., Jonas, Jean-Christophe, Poitout, Vincent, Kulkarni, Rohit N., Mauvais-Jarvis, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912162/
https://www.ncbi.nlm.nih.gov/pubmed/24498408
http://dx.doi.org/10.1371/journal.pone.0087941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912162/
https://www.ncbi.nlm.nih.gov/pubmed/24498408
http://dx.doi.org/10.1371/journal.pone.0087941

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