Human FXR Regulates SHP Expression through Direct Binding to an LRH-1 Binding Site, Independent of an IR-1 and LRH-1

BACKGROUND: Farnesoid X receptor/retinoid X receptor-alpha (FXR/RXRα) is the master transcriptional regulator of bile salt synthesis and transport in liver and intestine. FXR is activated by bile acids, RXRα by the vitamin A–derivative 9-cis retinoic acid (9cRA). Remarkably, 9cRA inhibits binding of...

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Detalles Bibliográficos
Autores principales: Hoeke, Martijn O., Heegsma, Janette, Hoekstra, Mark, Moshage, Han, Faber, Klaas Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912179/
https://www.ncbi.nlm.nih.gov/pubmed/24498423
http://dx.doi.org/10.1371/journal.pone.0088011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912179/
https://www.ncbi.nlm.nih.gov/pubmed/24498423
http://dx.doi.org/10.1371/journal.pone.0088011

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