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Structural and Functional Characterization of Cargo-Binding Sites on the μ4-Subunit of Adaptor Protein Complex 4

Adaptor protein (AP) complexes facilitate protein trafficking by playing key roles in the selection of cargo molecules to be sorted in post-Golgi compartments. Four AP complexes (AP-1 to AP-4) contain a medium-sized subunit (μ1-μ4) that recognizes YXXØ-sequences (Ø is a bulky hydrophobic residue), w...

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Detalles Bibliográficos
Autores principales: Ross, Breyan H., Lin, Yimo, Corales, Esteban A., Burgos, Patricia V., Mardones, Gonzalo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912200/
https://www.ncbi.nlm.nih.gov/pubmed/24498434
http://dx.doi.org/10.1371/journal.pone.0088147