p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression

Constitutive heterochromatin is important for maintaining chromosome stability but also delays the repair of DNA double strand breaks (DSB). DSB repair in complex mammalian genomes involves a fast phase (2–6 hrs) where most of the breaks are rapidly repaired, and a slow phase (up to 24 hrs) where th...

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Detalles Bibliográficos
Autores principales: Zheng, Hong, Chen, Lihong, Pledger, W. Jack, Fang, Jia, Chen, Jiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912226/
https://www.ncbi.nlm.nih.gov/pubmed/23376847
http://dx.doi.org/10.1038/onc.2013.6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912226/
https://www.ncbi.nlm.nih.gov/pubmed/23376847
http://dx.doi.org/10.1038/onc.2013.6

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