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p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression
Constitutive heterochromatin is important for maintaining chromosome stability but also delays the repair of DNA double strand breaks (DSB). DSB repair in complex mammalian genomes involves a fast phase (2–6 hrs) where most of the breaks are rapidly repaired, and a slow phase (up to 24 hrs) where th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912226/ https://www.ncbi.nlm.nih.gov/pubmed/23376847 http://dx.doi.org/10.1038/onc.2013.6 |