Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the ch...

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Detalles Bibliográficos
Autores principales: Simon, Jeremy M., Hacker, Kathryn E., Singh, Darshan, Brannon, A. Rose, Parker, Joel S., Weiser, Matthew, Ho, Thai H., Kuan, Pei-Fen, Jonasch, Eric, Furey, Terrence S., Prins, Jan F., Lieb, Jason D., Rathmell, W. Kimryn, Davis, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912414/
https://www.ncbi.nlm.nih.gov/pubmed/24158655
http://dx.doi.org/10.1101/gr.158253.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912414/
https://www.ncbi.nlm.nih.gov/pubmed/24158655
http://dx.doi.org/10.1101/gr.158253.113

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