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Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project
Background: Higher dietary intake of potassium, calcium, and magnesium is protective against ischemic strokes while also being associated with a decreased risk of all-cause dementia. The effect of dietary iron intake on cerebral function is less clear but iron is also implicated in Alzheimer neuropa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912433/ https://www.ncbi.nlm.nih.gov/pubmed/24550825 http://dx.doi.org/10.3389/fnagi.2014.00004 |
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author | Cherbuin, Nicolas Kumar, Rajeev Sachdev, Perminder S. Anstey, Kaarin J. |
author_facet | Cherbuin, Nicolas Kumar, Rajeev Sachdev, Perminder S. Anstey, Kaarin J. |
author_sort | Cherbuin, Nicolas |
collection | PubMed |
description | Background: Higher dietary intake of potassium, calcium, and magnesium is protective against ischemic strokes while also being associated with a decreased risk of all-cause dementia. The effect of dietary iron intake on cerebral function is less clear but iron is also implicated in Alzheimer neuropathology. The aim of this study was to investigate whether dietary intake of these minerals was also associated with increased risk of mild cognitive impairment (MCI, amnestic) and other mild cognitive disorders (MCD). Methods: Associations between dietary mineral intake and risk of MCI/MCD were assessed in cognitively healthy individuals (n = 1406, 52% female, mean age 62.5 years) living in the community, who were followed up over 8 years. Relative risk was assessed with Cox hazard ratios (HRs) after controlling for health and socio-demographic covariates. Results: Higher magnesium intake was associated with a reduced risk of developing MCI/MCD (MCI: HR 0.07, 95% confidence interval (CI) 0.01–0.56, p = 0.013; MCD: HR 0.47, 95% CI 0.22–0.99, p = 0.046) in multivariate analyses. Higher intake of potassium (MCI: HR 1.09, 95% CI 1.01–1.17, p = 0.028; MCD: HR 1.05, 95% CI 0.99–1.10, p = 0.107) and iron (MCI: HR 1.54, 95% CI 1.03–2.29, p = 0.034) was associated with an increased risk of developing MCI/MCD. Conclusion: These findings suggest that dietary intake of minerals known to be implicated in biological processes associated with vascular and Alzheimer’s pathology may contribute to disease progression earlier in the disease process and require further attention. |
format | Online Article Text |
id | pubmed-3912433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39124332014-02-18 Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project Cherbuin, Nicolas Kumar, Rajeev Sachdev, Perminder S. Anstey, Kaarin J. Front Aging Neurosci Neuroscience Background: Higher dietary intake of potassium, calcium, and magnesium is protective against ischemic strokes while also being associated with a decreased risk of all-cause dementia. The effect of dietary iron intake on cerebral function is less clear but iron is also implicated in Alzheimer neuropathology. The aim of this study was to investigate whether dietary intake of these minerals was also associated with increased risk of mild cognitive impairment (MCI, amnestic) and other mild cognitive disorders (MCD). Methods: Associations between dietary mineral intake and risk of MCI/MCD were assessed in cognitively healthy individuals (n = 1406, 52% female, mean age 62.5 years) living in the community, who were followed up over 8 years. Relative risk was assessed with Cox hazard ratios (HRs) after controlling for health and socio-demographic covariates. Results: Higher magnesium intake was associated with a reduced risk of developing MCI/MCD (MCI: HR 0.07, 95% confidence interval (CI) 0.01–0.56, p = 0.013; MCD: HR 0.47, 95% CI 0.22–0.99, p = 0.046) in multivariate analyses. Higher intake of potassium (MCI: HR 1.09, 95% CI 1.01–1.17, p = 0.028; MCD: HR 1.05, 95% CI 0.99–1.10, p = 0.107) and iron (MCI: HR 1.54, 95% CI 1.03–2.29, p = 0.034) was associated with an increased risk of developing MCI/MCD. Conclusion: These findings suggest that dietary intake of minerals known to be implicated in biological processes associated with vascular and Alzheimer’s pathology may contribute to disease progression earlier in the disease process and require further attention. Frontiers Media S.A. 2014-02-04 /pmc/articles/PMC3912433/ /pubmed/24550825 http://dx.doi.org/10.3389/fnagi.2014.00004 Text en Copyright © 2014 Cherbuin, Kumar, Sachdev and Anstey. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cherbuin, Nicolas Kumar, Rajeev Sachdev, Perminder S. Anstey, Kaarin J. Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project |
title | Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project |
title_full | Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project |
title_fullStr | Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project |
title_full_unstemmed | Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project |
title_short | Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project |
title_sort | dietary mineral intake and risk of mild cognitive impairment: the path through life project |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912433/ https://www.ncbi.nlm.nih.gov/pubmed/24550825 http://dx.doi.org/10.3389/fnagi.2014.00004 |
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