Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity

BACKGROUND: Induced pluripotent stem cells (iPSCs) derived from somatic cells have enormous potential for clinical applications. Notably, it was recently reported that reprogramming from somatic cells to iPSCs can induce genomic copy number variation (CNV), which is one of the major genetic causes o...

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Detalles Bibliográficos
Autores principales: Chen, Yulin, Guo, Lin, Chen, Jiekai, Zhao, Xiangjie, Zhou, Weichen, Zhang, Cheng, Wang, Jiucun, Jin, Li, Pei, Duanqing, Zhang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912500/
https://www.ncbi.nlm.nih.gov/pubmed/24472662
http://dx.doi.org/10.1186/1471-2164-15-79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912500/
https://www.ncbi.nlm.nih.gov/pubmed/24472662
http://dx.doi.org/10.1186/1471-2164-15-79

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