A G protein–coupled receptor and the intracellular synthase of its agonist functionally cooperate

Export of newly synthesized G protein–coupled receptors (GPCRs) remains poorly characterized. We show in this paper that lipocalin-type prostaglandin D(2) (PGD(2)) synthase (L-PGDS) interacts intracellularly with the GPCR DP1 in an agonist-independent manner. L-PGDS promotes cell surface expression...

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Detalles Bibliográficos
Autores principales: Binda, Chantal, Génier, Samuel, Cartier, Andréane, Larrivée, Jean-François, Stankova, Jana, Young, Jason C., Parent, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912537/
https://www.ncbi.nlm.nih.gov/pubmed/24493589
http://dx.doi.org/10.1083/jcb.201304015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912537/
https://www.ncbi.nlm.nih.gov/pubmed/24493589
http://dx.doi.org/10.1083/jcb.201304015

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