An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic vestibule of the Sec61 channel into the lipid bilayer. Molecular insight into TMD integration has been hampered by the difficulty of characterizing intermediates during this in...

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Detalles Bibliográficos
Autores principales: MacKinnon, Andrew L, Paavilainen, Ville O, Sharma, Ajay, Hegde, Ramanujan S, Taunton, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913039/
https://www.ncbi.nlm.nih.gov/pubmed/24497544
http://dx.doi.org/10.7554/eLife.01483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913039/
https://www.ncbi.nlm.nih.gov/pubmed/24497544
http://dx.doi.org/10.7554/eLife.01483

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