Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma

BACKGROUND: Parental smoking is known to worsen asthma symptoms in children and to make them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative stress from tobacco smoke has been reported to impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt...

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Detalles Bibliográficos
Autores principales: Kobayashi, Yoshiki, Bossley, Cara, Gupta, Atul, Akashi, Kenichi, Tsartsali, Lemonia, Mercado, Nicolas, Barnes, Peter J., Bush, Andrew, Ito, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Chest Physicians 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913299/
https://www.ncbi.nlm.nih.gov/pubmed/24030221
http://dx.doi.org/10.1378/chest.13-0835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913299/
https://www.ncbi.nlm.nih.gov/pubmed/24030221
http://dx.doi.org/10.1378/chest.13-0835

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