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Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma
BACKGROUND: Parental smoking is known to worsen asthma symptoms in children and to make them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative stress from tobacco smoke has been reported to impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American College of Chest Physicians
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913299/ https://www.ncbi.nlm.nih.gov/pubmed/24030221 http://dx.doi.org/10.1378/chest.13-0835 |