Novel Bifunctional Single-Chain Variable Antibody Fragments to Enhance Virolysis by Complement: Generation and Proof-of-Concept

When bound to the envelope of viruses, factor H (FH), a soluble regulator of complement activation, contributes to the protection against a potent immune defense mechanism, the complement-mediated lysis (CML). Thus, removing FH from the surface renders viruses, such as HIV, susceptible to CML. For a...

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Detalles Bibliográficos
Autores principales: Huber, Georg, Bánki, Zoltán, Kunert, Renate, Stoiber, Heribert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913500/
https://www.ncbi.nlm.nih.gov/pubmed/24524088
http://dx.doi.org/10.1155/2014/971345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913500/
https://www.ncbi.nlm.nih.gov/pubmed/24524088
http://dx.doi.org/10.1155/2014/971345

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