Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 63...

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Detalles Bibliográficos
Autores principales: Attia, Mohamed I., Aboul-Enein, Mohamed N., El-Azzouny, Aida A., Maklad, Yousreya A., Ghabbour, Hazem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913509/
https://www.ncbi.nlm.nih.gov/pubmed/24523636
http://dx.doi.org/10.1155/2014/357403
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author Attia, Mohamed I.
Aboul-Enein, Mohamed N.
El-Azzouny, Aida A.
Maklad, Yousreya A.
Ghabbour, Hazem A.
author_facet Attia, Mohamed I.
Aboul-Enein, Mohamed N.
El-Azzouny, Aida A.
Maklad, Yousreya A.
Ghabbour, Hazem A.
author_sort Attia, Mohamed I.
collection PubMed
description Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μmol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds 6a–p was confirmed via single crystal X-ray structure of compound 6g.
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spelling pubmed-39135092014-02-12 Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides Attia, Mohamed I. Aboul-Enein, Mohamed N. El-Azzouny, Aida A. Maklad, Yousreya A. Ghabbour, Hazem A. ScientificWorldJournal Research Article Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μmol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds 6a–p was confirmed via single crystal X-ray structure of compound 6g. Hindawi Publishing Corporation 2014-01-12 /pmc/articles/PMC3913509/ /pubmed/24523636 http://dx.doi.org/10.1155/2014/357403 Text en Copyright © 2014 Mohamed I. Attia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Attia, Mohamed I.
Aboul-Enein, Mohamed N.
El-Azzouny, Aida A.
Maklad, Yousreya A.
Ghabbour, Hazem A.
Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
title Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
title_full Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
title_fullStr Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
title_full_unstemmed Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
title_short Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
title_sort anticonvulsant potential of certain new (2e)-2-[1-aryl-3-(1h-imidazol-1-yl)propylidene]-n-(aryl/h)hydrazinecarboxamides
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913509/
https://www.ncbi.nlm.nih.gov/pubmed/24523636
http://dx.doi.org/10.1155/2014/357403
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