Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies

Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in lethality and severe developmental defects. Despi...

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Detalles Bibliográficos
Autores principales: Osborn, Daniel P. S., Roccasecca, Rosa Maria, McMurray, Fiona, Hernandez-Hernandez, Victor, Mukherjee, Sriparna, Barroso, Inês, Stemple, Derek, Cox, Roger, Beales, Philip L., Christou-Savina, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913654/
https://www.ncbi.nlm.nih.gov/pubmed/24503721
http://dx.doi.org/10.1371/journal.pone.0087662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913654/
https://www.ncbi.nlm.nih.gov/pubmed/24503721
http://dx.doi.org/10.1371/journal.pone.0087662

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