Direct and Indirect Targets of the E2A-PBX1 Leukemia-Specific Fusion Protein

E2A-PBX1 is expressed as a result of the t(1;19) chromosomal translocation in nearly 5% of cases of childhood acute lymphoblastic leukemia. The E2A-PBX1 chimeric transcription factor contains the N-terminal transactivation domain of E2A (TCF3) fused to the C-terminal DNA-binding homeodomain of PBX1....

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Detalles Bibliográficos
Autores principales: Diakos, Christofer, Xiao, Yuanyuan, Zheng, Shichun, Kager, Leo, Dworzak, Michael, Wiemels, Joseph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913655/
https://www.ncbi.nlm.nih.gov/pubmed/24503810
http://dx.doi.org/10.1371/journal.pone.0087602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913655/
https://www.ncbi.nlm.nih.gov/pubmed/24503810
http://dx.doi.org/10.1371/journal.pone.0087602

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