Development of a Human Dihydroorotate Dehydrogenase (hDHODH) Pharma-Similarity Index Approach with Scaffold-Hopping Strategy for the Design of Novel Potential Inhibitors

Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because it is extensively used by proliferating cells, its inhibition in autoimmune and inflammatory diseases, cancers, and multiple sclerosis is of substantial clinical importance. In this study, we had two aims....

Descripción completa

Detalles Bibliográficos
Autores principales: Shih, Kuei-Chung, Lee, Chi-Ching, Tsai, Chi-Neu, Lin, Yu-Shan, Tang, Chuan-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913663/
https://www.ncbi.nlm.nih.gov/pubmed/24504131
http://dx.doi.org/10.1371/journal.pone.0087960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913663/
https://www.ncbi.nlm.nih.gov/pubmed/24504131
http://dx.doi.org/10.1371/journal.pone.0087960

Ejemplares similares