Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

Inflammatory hepatocellular adenomas (IHCAs) are benign liver lesions that can be characterized histologically by the presence of an inflammatory infiltrate and at the molecular level by the overexpression of acute phase inflammatory response genes. Recurrent somatic mutations of the interleukin-6 (...

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Detalles Bibliográficos
Autores principales: Poussin, Karine, Pilati, Camilla, Couchy, Gabrielle, Calderaro, Julien, Bioulac-Sage, Paulette, Bacq, Yannick, Paradis, Valérie, Leteurtre, Emmanuelle, Sturm, Nathalie, Ramos, Jeanne, Guettier, Catherine, Bardier-Dupas, Armelle, Boulai, Anais, Wendum, Dominique, Selves, Janick, Izard, Tina, Nault, Jean-Charles, Zucman-Rossi, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913689/
https://www.ncbi.nlm.nih.gov/pubmed/24501689
http://dx.doi.org/10.4161/onci.27090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913689/
https://www.ncbi.nlm.nih.gov/pubmed/24501689
http://dx.doi.org/10.4161/onci.27090

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