A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP

BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferentially by the N domain active center. Elevated Ac-SDKP...

Descripción completa

Detalles Bibliográficos
Autores principales: Danilov, Sergei M., Wade, Michael S., Schwager, Sylva L., Douglas, Ross G., Nesterovitch, Andrew B., Popova, Isolda A., Hogarth, Kyle D., Bhardwaj, Nakul, Schwartz, David E., Sturrock, Edward D., Garcia, Joe G. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913711/
https://www.ncbi.nlm.nih.gov/pubmed/24505347
http://dx.doi.org/10.1371/journal.pone.0088001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913711/
https://www.ncbi.nlm.nih.gov/pubmed/24505347
http://dx.doi.org/10.1371/journal.pone.0088001

Ejemplares similares